Cathepsin B-Overexpressed Tumor Cell Activatable Albumin-Binding Doxorubicin Prodrug for Cancer-Targeted Therapy

Cho, Hanhee and Shim, Man Kyu and Yang, Suah and Song, Sukyung and Moon, Yujeong and Kim, Jinseong and Byun, Youngro and Ahn, Cheol-Hee and Kim, Kwangmeyung (2021) Cathepsin B-Overexpressed Tumor Cell Activatable Albumin-Binding Doxorubicin Prodrug for Cancer-Targeted Therapy. Pharmaceutics, 14 (1). p. 83. ISSN 1999-4923

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Abstract

Prodrugs are bioreversible medications that should undergo an enzymatic or chemical transformation in the tumor microenvironment to release active drugs, which improve cancer selectivity to reduce toxicities of anticancer drugs. However, such approaches have been challenged by poor therapeutic efficacy attributed to a short half-life and low tumor targeting. Herein, we propose cathepsin B-overexpressed tumor cell activatable albumin-binding doxorubicin prodrug, Al-ProD, that consists of a albumin-binding maleimide group, cathepsin B-cleavable peptide (FRRG), and doxorubicin. The Al-ProD binds to in situ albumin, and albumin-bound Al-ProD indicates high tumor accumulation with prolonged half-life, and selctively releases doxorubicin in cathepsin B-overexpressed tumor cells, inducing a potent antitumor efficacy. Concurrently, toxicity of Al-ProD toward normal tissues with innately low cathepsin B expression is significantly reduced by maintaining an inactive state, thereby increasing the safety of chemotherapy. This study offers a promising approach for effective and safe chemotherapy, which may open new avenues for drug design and translational medicine.

Item Type: Article
Uncontrolled Keywords: prodrug; albumin; drug delivery; targeted therapy; chemotherapy
Subjects: Euro Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 11 Nov 2022 04:35
Last Modified: 09 Feb 2024 03:48
URI: http://publish7promo.com/id/eprint/97

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