Arias, María L. and Corrales, Eugenia and Poveda, Rebeca and Cabezas, Jorge A. (2018) Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs. International Journal of Organic Chemistry, 08 (01). pp. 115-124. ISSN 2161-4687
![[thumbnail of IJOC_2018030614322121.pdf]](http://publish7promo.com/style/images/fileicons/text.png)
IJOC_2018030614322121.pdf - Published Version
Download (391kB)
Abstract
Natural product jacaranone, 1, and three analog derivatives were synthesized and their apoptotic and necrotic activity against four cancer cell lines was tested. One of these derivatives 7, was more active than the natural product, and exhibited an important necrotic effect against three of the cell lines tested (ovarian carcinoma, liver cancer and breast cancer cells). Derivative 6 was more active than the natural product, and showed a significant apoptotic activity against breast cancer and ovarian carcinoma cells. Some derivatives analyzed in this study showed promising anti-tumor results, nevertheless, further studies have to be done in order to determine their in vivo activity, their mechanism as well as their safety and stability.
Item Type: | Article |
---|---|
Subjects: | Euro Archives > Chemical Science |
Depositing User: | Managing Editor |
Date Deposited: | 06 Apr 2023 03:57 |
Last Modified: | 23 Mar 2024 03:59 |
URI: | http://publish7promo.com/id/eprint/827 |