Transcriptomic profiling of adjuvant colorectal cancer identifies three key prognostic biological processes and a disease specific role for granzyme B

Daemen, Anneleen and Udyavar, Akshata R. and Sandmann, Thomas and Li, Congfen and Bosch, Linda J. W. and O’Gorman, William and Li, Yijin and Au-Yeung, Amelia and Takahashi, Chikara and Kabbarah, Omar and Bourgon, Richard and Hegde, Priti and Bais, Carlos and Das Thakur, Meghna and Paliouras, Miltiadis (2021) Transcriptomic profiling of adjuvant colorectal cancer identifies three key prognostic biological processes and a disease specific role for granzyme B. PLOS ONE, 16 (12). e0262198. ISSN 1932-6203

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Official URL: https://doi.org/10.1371/journal.pone.0262198

Abstract

Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with a 5% 5-year survival rate for metastatic disease, yet with limited therapeutic advancements due to insufficient understanding of and inability to accurately capture high-risk CRC patients who are most likely to recur. We aimed to improve high-risk classification by identifying biological pathways associated with outcome in adjuvant stage II/III CRC.

Item Type:	Article
Subjects:	Euro Archives > Medical Science
Depositing User:	Managing Editor
Date Deposited:	02 Dec 2022 03:59
Last Modified:	19 Sep 2023 04:52
URI:	http://publish7promo.com/id/eprint/665

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