Increase in Incidence of Gall-Bladder Carcinoma in Tea-Estate Workers in a Tertiary Care Centre

Objective: To calculate the increase in carcinoma Gall-Bladder in Tea-Estate workers in a Tertiary Care Centre (AMCH)

Introduction: Gallbladder carcinoma (GBC) arises from the epithelial lining of the gallbladder (GB) and the cystic duct. It is the most common biliary tract malignancy worldwide. North, East, Northeast and Central India are regions with high incidence of gallbladder carcinoma in contrast to South and West India.

Material and Methodology: Patients who were diagnosed with carcinoma GB, admitted under General Surgery, AMCH from july 2014- july2022 have been included in the study.

Results:

In Male: O3 Cases in 242 Patients with G.B Pathology (b/w 2014-18) and 05 Cases in 274 Patients with G.B Pathology (b/w 2018-22).

In Female: 256 Cases in 2083 Patients with G.B Pathology (b/w 2014-18) and 334 Cases in 2530 Patients with G.B Pathology (b/w 2018-22).

In Male Tea-Garden Population: The rate was 23.07 % (b/w 2014-18) and 23.52% (b/w 2018-22)

In Female Tea-Garden Population: The rate was 60.1 % (b/w 2014-18) and 68.56 % (b/w 2018-22).

Discussion: Dimethoate, Tetradifon, Monocrotophos are few of the toxic compound used as pesticide in the tea garden.

Pesticides can cause intoxication in the individuals who manipulate them through either inhalation, ingestion, or dermal contact. It causes damage to the DNA. Although it is mentioned in many research articles about the strong association between the pesticides and carcinogenesis; the use of such substance is not banned nor there is awareness created regarding the maximum and minimum exposure amount.

Conclusion: The incidence of Gall Bladder carcinoma are on the rise, as per study in the tertiary care centre. Cases are more rising in female as compared to male. Cases of Carcinoma Gall Bladder in north-east region is significantly high and are on the rise; suspicion regarding the use of pesticides in the Tea-gardens.