Hussien, Emad Mohamed and Mohammed, Israa Abd El-Ghafar and El-Razeq, Sawsan Abdel-Moneim Abd (2019) Simultaneous Determination of Camylofin Dihydrochloride and Paracetamol Using Differential Pulse Voltammetry in Micellar Media. In: New Insights on Chemical Research Vol. 1. B P International, pp. 128-140. ISBN 978-93-89246-83-4
Full text not available from this repository.Abstract
Simple and sensitive differential pulse voltammetric (DPV) method has been developed for
simultaneous determination of camylofin-2HCl and paracetamol. The electrochemical oxidation of
camylofin was studied at carbon paste electrode using cyclic and differential pulse voltammetry. A
reproducible and reliable oxidation current peak was obtained at pH 7. The oxidation current was
enhanced in presence of sodium dodecylsulphate as an erosion reagent. Under optimal conditions the
oxidation current was proportional to camylofin concentration in the range from 5.0 to 100.0 μM.
Besides, the method was linear for paracetamol which is an active ingredient in the concentration
range from 5.0 to 1000.0 μM. The proposed DPV method was selective for simultaneous
determination of the two drugs with mean recovery of 99.58±2.13% and 99.44±0.57% for camylofin-
2HCl and paracetamol, respectively. The method was validated according to ICH guidelines and
successfully applied for the determination of the two drugs in combined pharmaceutical formulations.
| Item Type: | Book Section |
|---|---|
| Subjects: | Euro Archives > Chemical Science |
| Depositing User: | Managing Editor |
| Date Deposited: | 12 Dec 2023 03:42 |
| Last Modified: | 12 Dec 2023 03:42 |
| URI: | http://publish7promo.com/id/eprint/3976 |
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