Natural Acid Catalyzed Synthesis and Biological Evaluation of Dihydropyrimidinone Derivative Synthesied from Vanillin, Ethylacetoacetate and Urea

Green synthesis of organic compounds using solvent-free condition has gained popularity in recent
years, since the majority of solvents are either toxic or flammable. Dihydropyrimidinones are very
important heterocyclic motif in the realm of natural and synthetic organic chemistry. Natural acid
catalyst is employed for organic synthesis, which effectively catalyses various organic
transformations. The objective of the present research consists of green methodology for the
synthesis of dihydropyrimidinone derivative. The present study focuses on the synthesis,
characterization and biological evaluation of dihydropyrimidinone derivative ethyl-4-(4-hydroxy-3-
methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate from vanillin,
ethylacetoacetate and urea using gooseberry extract. The antimicrobial activity reveals that the
synthesized dihydropyrimidinone can be used for the treatment of diseases caused by microbes. The
synthesised compound is characterized by UV-Visible and FT-IR spectroscopy. The synthesised
compound shows antibacterial, antifungal, antioxidant and anti-helminthic activities. This natural acid
catalysed synthesis is safe, eco-friendly and does not employ any toxic materials and quantifying it as
a green approach for the synthesis of organic compounds.