A Recent Kinetic Studies of Interaction of Ni(II) with d-2,2-(Ethylenediimino)-di-1-Butanol

The complexation kinetics between Ni(II) with d-2,2-(ethylenediimino)-di-1-butanol has been
investigated at 25, 30, 35 and 40 ± 0.05°C in the pH range 6.18-7.41 using Aminco Morrow stopped
flow spectrophotometer. Its antibacterial spectrum is limited to mycobacteria and only growing cells
are affected by inhibiting mycobacterial RNA synthesis. Like EDTA, it is a good chelating agent. The
ionic strength was maintained at 0.1M KNO3. The anionic form of d-2,2-(ethylenediimino)-di-1-butanol
is more reactive and the protonated form interacts only to a small extent. Kinetic results indicate that
the ligand is not involved in the rate determining step which is, in fact, associated with the release of a
water molecule from the shell of the metal ions prior to complexation with the ligand. Enthalpy,
entropy of activation, energy of the molecule and heat of formation were also calculated. A
mechanism consistent with the kinetic data has been suggested.