Computational Study of the FOXP3 Gene in T-Cell Oncogenesis

The study objected to investigating the FOXP3 gene from the FOX family between two mammalian genomes (i.e. Homo sapiens and Mus musculus). The observations of the FOXP3 gene are currently mandatory to explore the molecular function and mechanisms of Treg differentiation and immunosuppressive function in a particular organism. The FOXP3 gene, which is encoded by the human X chromosome, is a new regulator of T-cell differentiation and immunosuppressive activity. The FOXP3 gene, which is a nuclear transcription factor, controls lineage-specific differentiation in the Tregs that maintain immunological homeostasis. The immune response to self-antigens, allergens, and tumors is influenced by regulatory T-cells, often known as Treg or CD4+ cells. However, the FOXP3 gene exhibits both tumor-promoting and -suppressive behavior throughout carcinogenesis. According to impacts on proliferation and apoptosis, the FOXP3 gene suppresses cancer, according to a new empirical investigation. So, perform bioinformatics and computational pipeline and tools to the current knowledge of the entire FOX family for the immune-responsive FOXP3 transcription factor gene in the mammalian genome. The study method may be valuable for the functional analysis of specific gene and their families in particular organisms. The study outcome suggested FOXP3 and FOX family in the model organism’s genome. Also, findings data suggested the FOX family reveal an essential role during development. The composition of nucleotide and peptide, structure, domain, motifs, phylogeny, gene expression, gene network, and chromosome location analysis suggested that the FOXP3 gene is T-cell-dependent. In contrast, the FOXP3 gene's functional regulation demonstrates tumour suppressor activity. The study of the data revealed that the FOX family is crucial to growth. The T-cell's limited FOXP3 gene expression in rays is immune-privileged. A unique immunological mechanism and immune homeostasis may be maintained by the critical role of the FOXP3 gene in tumor cells.