Fatma, Guesmi and Ahmed, Landoulsi (2018) Pathological Overview and Antioxidant Status of Thyme on H2O2-induced Spleen Tissues Damage. Annual Research & Review in Biology, 27 (6). pp. 1-7. ISSN 2347565X
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Abstract
Objectives: To study the preventive effect of Thymus algeriensis essential oil (TAS) against hydrogen peroxide (H2O2)-induced spleen toxicity in rats.
Materials and Methods: Rats were treated with Hydrophobic fractions of Thymus algeriensis (180 mg/kg body weight, n=6), H2O2 (0.1, 1 mmol/L body weight, n=6) and the exposure to both drugs orally for 15 days. Histological examination was performed and the levels of biochemical parameters and lipid peroxides were determined.
Results: In spleen tissue protein, catalase, superoxide dismutase, and glutathione (GST, GPx and GSH) levels were increased significantly (P<0.05) in the essential oil pretreated rats when compared to H2O2. TAS decreased the intracellular malondialdehyde (MDA) levels in spleen tissues. Vascular congestion was seen in spleen of high dose H2O2-treated rats and normal architecture of tissues was observed in other groups.
Conclusion: The biochemical parameters and histopathology examination support the cytoprotective effect of Thyme which could be attributed to terpenes.
Item Type: | Article |
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Subjects: | Euro Archives > Biological Science |
Depositing User: | Managing Editor |
Date Deposited: | 16 Sep 2023 05:28 |
Last Modified: | 16 Sep 2023 05:28 |
URI: | http://publish7promo.com/id/eprint/3072 |