Djibrilla-Almoustapha, Amadou and Mamane-Brah, Moustapha and Elhadj-Chefou, Moustapha and Badé, Maman Rabiou and Abba-Ousmane, Faiza and Ousseini, Fanta and Abdoulaye-Soumana, Oumoulkairou and Malam-Abdou, Badé (2022) Chronic Lymphocytic Leukemia of <i>del</i> 17p in a Young Subject: About a Case and Reviewed a Literature. Open Journal of Blood Diseases, 12 (04). pp. 103-109. ISSN 2164-3180
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Abstract
Objective: To report a case of Chronic Lymphoid Leukemia in a 28-year-old young subject, with variable clinical features and a TP53 mutation, diagnosed and followed up in the Onco-Hematology department of the HNN. Observation: 28-year-old patient, having consulted for polyadenopathy and physical asthenia, whose clinical examination found a conscious patient, submaxillary, laterocervical, axillary and inguinal lymphadenopathy, bilateral, symmetrical, painless and non-compressive whose largest measures 3 cm in diameter. Hepato-splenomegaly and epistaxis. Predominantly lymphocyte hyperleukocytosis, immunophenotyping revealed low CD19+, CD5+, CD23+, CD20 monoclonal B lymphoid proliferation. The Matutes score was 4. A karyotype showed a three-chromosome translocation; the short arm of a chromosome 2, the long arm of a chromosome 11 and the long arm of a chromosome 13, and a translocation between the long arm of a chromosome 6 and the long arm of a chromosome 18. A FISH objectified a led 17p. The diagnosis of Binet Stage C CLL with positive del 17p and complex karyotype was retained. Despite the poor prognosis, the R-C (Rituximab-Chlorambucil) protocol was instituted with once-weekly transfusions. The patient is still alive in partial clinical and biological remission. Conclusion: Despite therapeutic progress, the presence of the deletion of chromosome 17p with TP53 mutation and the young age of the patient does not change the patient’s prognosis.
Item Type: | Article |
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Subjects: | Euro Archives > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 15 Apr 2023 05:40 |
Last Modified: | 22 Sep 2023 07:59 |
URI: | http://publish7promo.com/id/eprint/2207 |