Chen, Lijuan and Li, Daojie and Shao, Ye and Wang, Hui and Liu, Yuqing and Zhang, Yunhua (2019) Identifying Microbiota Signature and Functional Rules Associated With Bacterial Subtypes in Human Intestine. Frontiers in Genetics, 10. ISSN 1664-8021
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Abstract
Gut microbiomes are integral microflora located in the human intestine with particular symbiosis. Among all microorganisms in the human intestine, bacteria are the most significant subgroup that contains many unique and functional species. The distribution patterns of bacteria in the human intestine not only reflect the different microenvironments in different sections of the intestine but also indicate that bacteria may have unique biological functions corresponding to their proper regions of the intestine. However, describing the functional differences between the bacterial subgroups and their distributions in different individuals is difficult using traditional computational approaches. Here, we first attempted to introduce four effective sets of bacterial features from independent databases. We then presented a novel computational approach to identify potential distinctive features among bacterial subgroups based on a systematic dataset on the gut microbiome from approximately 1,500 human gut bacterial strains. We also established a group of quantitative rules for explaining such distinctions. Results may reveal the microstructural characteristics of the intestinal flora and deepen our understanding on the regulatory role of bacterial subgroups in the human intestine.
Item Type: | Article |
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Subjects: | Euro Archives > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 25 Feb 2023 06:17 |
Last Modified: | 13 Feb 2024 03:47 |
URI: | http://publish7promo.com/id/eprint/1937 |