Case Report: Hepatitis-associated Severe Aplastic Anemia of Unknown Etiology

Aplastic anemia (AA) is a life-threatening, autoimmune-mediated condition that targets bone marrow precursors leading to pancytopenia. Hepatitis-associated aplastic anemia (HAAA) is one of the rarest entities where the recovery of acute hepatitis is complicated by aplastic anemia. Hepatitis viruses (A-E, G), non-hepatitis viruses (cytomegalovirus, Epstein-Barr virus, HIV, Parvovirus B19, and echoviruses,) and drugs/toxins have been recognized as etiological agents. We present a case of a 29-year-old Asian male presenting with progressive jaundice, diagnosed to have acute cholestatic hepatitis, subsequently leading to severe aplastic anemia without an identified inciting agent.