Takale, Nilesh and Kaliyaperumal, Neelakandan and Mannathusamy, Gopalakrishnan and Govindasamy, Rajarajan (2022) Identification and Synthesis of Flecainide Acetate Impurities and Its Control to ICH Limit. Journal of Pharmaceutical Research International, 34 (47A). pp. 45-54. ISSN 2456-9119
![[thumbnail of 6478-Article Text-8810-3-10-20221006.pdf]](http://publish7promo.com/style/images/fileicons/text.png)
6478-Article Text-8810-3-10-20221006.pdf - Published Version
Download (508kB)
Abstract
The improved synthesis of Flecainide acetate (I) is conferred in this article. The chief intent to present this article is to identify and synthesis of the process related impurities of Flecainide acetate.
The article also provides the complete study and characterization of the process impurities. Most of the impurities are the in-situ generated intermediates which are tend to carryforward to the final step of synthesis. The more interesting part is the formation of 2,5 –bis (2,2,2-trifluoroethoxy)-N-((4-methylpiperidine-2-yl) methyl) benzamide impurity during Flecainide acetate synthesis.
The article confers the synthesis of 2,5 –bis (2,2,2-trifluoroethoxy)-N-((4-methylpiperidine-2-yl) methyl) benzamide and its control in Flecainide acetate.
Item Type: | Article |
---|---|
Subjects: | Euro Archives > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 14 Mar 2023 07:10 |
Last Modified: | 11 May 2024 08:10 |
URI: | http://publish7promo.com/id/eprint/1672 |