Navarro-Vera, Isabel and Casajús, José Antonio and López-Pérez, Manuel J. and Díez-Sánchez, Carmen (2018) Association of COL1A1 rs180012 SNP and Fibromyalgia Suggests the Implication of Collagen Structure in Musculoskeletal Pain. Advances in Bioscience and Biotechnology, 09 (02). pp. 83-89. ISSN 2156-8456
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Abstract
Fibromyalgia (FM) is a complex, chronic condition, which causes widespread musculoskeletal pain, fatigue and a variety of other symptoms. Many polymorphisms related to neuroendocrine system function as the ApoE isoforms, Val158Met polymorphism in COMT, as well as a 44 bp deletion located in 5-HTTLPR, have been studied. Other polymorphisms have been related to inflammatory response such as the 70 bp VNTR in IL-4 or to citokine levels. Furthermore, some studies focused on finding out new FM related SNPs, have been performed by genome wide association scan (GWAS). The target of this work was to study a possible linkage of a collagen type I polymorphism (COL1A1 rs180012 SNP) affecting bone mineralization, with fibromyalgia. Results obtained show a clear association of ss homozygous genotype with FM patients no dependent on bone mineralization.
Item Type: | Article |
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Subjects: | Euro Archives > Biological Science |
Depositing User: | Managing Editor |
Date Deposited: | 17 Mar 2023 04:40 |
Last Modified: | 04 Mar 2024 03:52 |
URI: | http://publish7promo.com/id/eprint/1149 |