Visualization of decreased docosahexaenoic acid in the hippocampus of rats fed an n – 3 fatty acid-deficient diet by imaging mass spectrometry

Taira, Shu and Hashimoto, Michio and Saito, Kazunori and Shido, Osamu (2012) Visualization of decreased docosahexaenoic acid in the hippocampus of rats fed an n – 3 fatty acid-deficient diet by imaging mass spectrometry. Journal of Biophysical Chemistry, 03 (03). pp. 221-226. ISSN 2153-036X

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Abstract

The present study employed an imaging mass spectrometry (IMS) method to evaluate the effect of dietary n – 3 fatty acids on the fatty acid composition in rat brain. Rats were divided into two groups and fed either an n – 3 fatty acid-deficient or adequate diet. We determined the decreased n – 3 fatty acids in the hippocampus of rats fed an n – 3 fatty acid-deficient diet compared to the control. IMS visualization was achieved at a resolution of 100 m in rat brain, and showed decreased docosahexaenoic acid (DHA)-containing phosphatidyl choline (PC) or phosphatidyl ethanolamine (PE) in the hippocampus of rats fed an n – 3 fatty acid-deficient diet.

Item Type: Article
Subjects: Euro Archives > Chemical Science
Depositing User: Managing Editor
Date Deposited: 10 Feb 2023 05:10
Last Modified: 10 Apr 2024 04:40
URI: http://publish7promo.com/id/eprint/1004

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