Molecular basis of scavenging effect of zonisamide on hydroxyl radical in vitro

Tanaka, Ken-ichi and Nanba, Takeshi and Furubayashi, Tomoyuki and Noda, Yasuko and James Willmore, Luther and Mori, Akitane (2012) Molecular basis of scavenging effect of zonisamide on hydroxyl radical in vitro. Journal of Biophysical Chemistry, 03 (03). pp. 256-258. ISSN 2153-036X

[thumbnail of JBPC20120300006_39558578.pdf] Text
JBPC20120300006_39558578.pdf - Published Version

Download (114kB)

Abstract

Zonisamide (ZNS), a commonly used anticonvulsant, scavenged hydroxyl radicals at a clinically relevant concentration. Reactants of ZNS with hydrogen peroxide and with hydrogen peroxide plus UV irradiation, yielding hydroxyl radicals, were analyzed by the LC/MS technique. Many small fragments were found in the both reactions, suggesting that ZNS was decomposed not only by hydroxyl radicals but also by hydrogen peroxide. Furthermore, mass-fragment-grams showed that m/z: 213 (ZNS itself) was decreased markedly and m/z: 118 (may be a decomposed product by ring cleavage of ZNS) was detected specifically by treatment with hydroxyl radical. These data suggested that ZNS may react directly with free radicals.

Item Type: Article
Subjects: Euro Archives > Chemical Science
Depositing User: Managing Editor
Date Deposited: 22 Mar 2023 04:19
Last Modified: 24 Jun 2024 04:01
URI: http://publish7promo.com/id/eprint/1000

Actions (login required)

View Item
View Item